Dr. Daniels is Professor of Pharmaceutical Sciences at Idaho State University College of Pharmacy. He was born in Los Angeles, California and received his undergraduate education in chemistry at Humboldt State University, Arcata, California. After completing his master's degree in organic chemistry at the University of Wisconsin - Milwaukee, he received his PhD in Pharmacology in 1982 from Stanford University School of Medicine. As a Monsanto Toxicology Postdoctoral Fellow he completed postdoctoral studies in biochemistry and cell biology at the University of California - San Francisco Medical Center, he remained with UCSF as an American Federation for Aging Research Fellow in cell biology and research assistant professor until 1988 when he joined the Idaho State University College of Pharmacy. In 1997 he was appointed chairman of the Department of Pharmaceutical Sciences at ISU. Dr. Daniels' research focuses on the effects of aging on the development of lymphoid cancers and the interaction of cellular signals that control cellular proliferation and cell death. His research has been funded by NIH, NSF-EPSCoR, non-profit research institutes, and private companies. Dr. Daniels is the founding director of the new ISU Biomedical Research Institute.
Recent Publications:
Irvin BJ, Luce CM, Smith LH, Daniels CK: Cyclic AMP- and IL6-Signaling Pathway Cross-Talk: Co-modulation of Proliferation and Apoptosis in the 7TD1 B Cell Hybridoma, Exp. Cell. Res., 265, 73-79, 2001.
Maderas-Kelly KJ, Daniels CK, Hegbloom M, Thompson M: Pharmacodynamic Characterization of Efflux and Topoisomerase IV-mediated Fluoroquinolone Resistance in Streptococcus pneumonia. J. Antimicrob. Chemother., 50, 211-218, 2002.
Wood SR, Zhao Q, Smith, Jr., LH, Daniels CK. Altered Morphology in Cultured Rat Intestinal Epithelial IEC-6 Cells is Associated with Alkaline Phosphatase Expression, Tissue and Cell, 35, 47 - 58, 2003.
Malthankar GV, White BK, Bhushan A, Daniels CK, Rodnick KJ, Lai JCK: Differential Lowering by Manganese Treatment of Activities of Glycolytic and Tricarboxylic Acid (TCA) Cycle Enzymes Investigated in Neuroblastoma and Astrocytoma Cells Is Associated with Manganese-Induced Cell Death, Neurochemical Research, 29, 709-717, 2004.
Hanson CL, Olbertz JL, Lai JCK, and Daniels CK: DEVD-Caspase Activation and Apoptotic Induction by Dibutyryl Cyclic AMP Without Altered Mitochondrial Membrane Potential in the 7TD1 B Cell Hybridoma: Modulation by Interleukin 6, Cell Death and Differentiation, 2006, submitted.
Puli S, Lai JCK, Edgley KL, Daniels CK, Bhushan A: Signaling Pathways mediating Manganese-Induced Neurotoxicity in Human Glioblastoma Cells (U87), Neurochem. Res., 2006, submitted.
Gangavarapu KJ,Pearce S, Olbertz J, Lai JCK, Daniels CK: Chronic Dexamethasone Treatment Results in Resistance and Altered IL6 Signaling in the 7TD1 Murine Hybridoma, Blood, 2006, submitted.
